POLEX™ is our DNA break detection platform — powered by nanopore sequencing and AI. We map single- and double-strand breaks at base resolution. We propose to use our novel chemistry of photon oxidation, turning raw ionic signal into genome-wide damage landscapes in hours, not weeks.
Where single-molecule genomics, deep bioinformatics, and machine learning converge to make DNA damage visible at the resolution disease actually happens.
To turn invisible DNA damage into actionable signal — giving every patient, every therapy, and every cell a clear readout of genome integrity.
A future in which DNA damage is no longer the silent driver of disease, but a measurable, interpretable, and treatable signal at the heart of every diagnosis and every cure.
Proposed photon-oxidation chemistry + long-read nanopore sequencing + deep learning, productised as POLEX™ — the first platform to map double-strand breaks at single-base resolution, genome-wide.
POLEX maps chromosomal fragility in every condition where DNA damage matters — pick a domain to see the disease atlas.
BRCA1/2 breast, glioblastoma, PDAC, MSI-H colorectal, HRD ovarian, leukemias, pediatric sarcomas. Sorted by prognosis, filterable by category.
Explore cancer atlas → 15 disordersAtaxia-telangiectasia, Huntington, ALS, Alzheimer's, Parkinson's, Friedreich's ataxia. When neurons can't keep up with a lifetime of DNA damage.
Explore neuro atlas → 15 syndromesHutchinson-Gilford, Werner, Cockayne, xeroderma pigmentosum, Bloom. Repair machinery failing at the source.
Explore progeroid atlas → 15 conditionsSCID (RAG / Artemis / DNA-PKcs), Fanconi anaemia, Nijmegen, hyper-IgM. V(D)J breaks that don’t resolve, and where gene therapy is changing outcomes.
Explore immuno atlas →Representative POLEX output. Each bar is one patient sample; colours split single-strand, double-strand, and complex lesions. Animates into view when scrolled to.
DNA breaks sit at the heart of cancer, ageing, neurodegeneration, and gene therapy.
Quantify DNA break burden after compound exposure — sensitive, dose-responsive, genome-wide.
Profile on- and off-target breaks from CRISPR, base editors, and prime editors at single-read resolution.
Track damage, repair kinetics, and mutational signatures across tumor models and patient samples.
Send samples — receive annotated break maps, hotspot calls, and an interactive report.
Joint programs with academic and industry partners on novel indications and assay development.
Click any card to read the full biography. We’re actively recruiting for CEO and CDO — if you’re interested, get in touch.
Looking for an experienced commercial leader to drive partnerships, fundraising and clinical rollout.
Building the POLEX platform end-to-end — from nanopore signal to clinical report.
Owning financial planning, fundraising, and grant accounting as we move from seed to clinical pilots.
DNA repair biology — bringing decades of mechanistic insight to POLEX’s break-calling models.
DNA replication and nanopore signal analysis — developer of DNAscent at the University of Cambridge.
Oncology — bridging clinical practice with platform development to make break detection actionable for clinicians.
Leading the ML, model-ops and clinical-data infrastructure for the POLEX platform.
Building the quality system — SOPs, validation, document control and audit-readiness for clinical-grade work.
Wet-lab scientist to build and validate nanopore break-detection assays. PhD + 3–5 yr post-doc preferred.
Bench scientist to run samples, build SOPs and support the assay team. MSc or BSc with lab experience.
We’ve raised £140k in non-dilutive grant funding to date — from BBSRC and the Guy Newton Translational Award via the Sir William Dunn School of Pathology, University of Oxford. We’re now opening a pre-seed round to scale the wet lab, build out the AI and clinical team, and validate POLEX across our first oncology and neurodegeneration cohorts.
Our work is built on the foundation of UK research councils and translation partners.
Hiring across science, engineering, and operations — CEO, CFO, CDO, QA Manager, Research Scientists, and Research Associates. Email your CV to shashisantosh2007@gmail.com.
